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TargetCathepsin B-like cysteine protease
LigandBDBM22101
Substrate/CompetitorBDBM22047
Meas. Tech.Enzyme Inhibition Assay
Temperature298.15±n/a K
IC50 2500±n/a nM
Commentsextracted
Citation Mallari, JPShelat, AAObrien, TCaffrey, CRKosinski, AConnelly, MHarbut, MGreenbaum, DMcKerrow, JHGuy, RK Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. J Med Chem51:545-52 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin B-like cysteine protease
Name:Cathepsin B-like cysteine protease
Synonyms:CPC | Cathepsin B-Like Cysteine Protease (TbcatB) | Cysteine peptidase C | TbcatB
Type:Enzyme
Mol. Mass.:37220.37
Organism:Trypanosoma brucei
Description:Enzyme was expressed in yeast Pichia pastoris.
Residue:340
Sequence:
MHLMRACITFCIASTAVVAVNAALVAEDAPVLSKAFVDRVNRLNRGIWKAKYDGVMQNIT
LREAKRLNGVIKKNNNASILPKRRFTEEEARAPLPSSFDSAEAWPNCPTIPQIADQSACG
SCWAVAAASAMSDRFCTMGGVQDVHISAGDLLACCSDCGDGCNGGDPDRAWAYFSSTGLV
SDYCQPYPFPHCSHHSKSKNGYPPCSQFNFDTPKCNYTCDDPTIPVVNYRSWTSYALQGE
DDYMRELFFRGPFEVAFDVYEDFIAYNSGVYHHVSGQYLGGHAVRLVGWGTSNGVPYWKI
ANSWNTEWGMDGYFLIRRGSSECGIEDGGSAGIPLAPNTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22101
BDBM22047
NameBDBM22101
Synonyms:6-{[(3,4-dichlorophenyl)methyl]amino}-9-(3-methoxypropyl)-9H-purine-2-carbonitrile | Compound 3{12,6}
TypeSmall organic molecule
Emp. Form.C17H16Cl2N6O
Mol. Mass.391.255
SMILESCOCCCn1cnc2c(NCc3ccc(Cl)c(Cl)c3)nc(nc12)C#N
Structure
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