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TargetPurine Nucleoside Phosphorylase (PNP)
LigandBDBM22108
Substrate/CompetitorBDBM22104
Meas. Tech.PNP Inhibition Assay
pH7.7±n/a
Temperature295.15±n/a K
Ki 1.8±0.2 nM
Km34000±n/a nM
Citation Evans GBFurneaux RHGreatrex BMurkin ASSchramm VLTyler PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem 51:948-56 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Purine Nucleoside Phosphorylase (PNP)
Name:Purine nucleoside phosphorylase
Synonyms:Inosine phosphorylase
Type:Enzyme
Mol. Mass.:32035.18
Organism:Bos taurus (bovine)
Description:n/a
Residue:289
Sequence:
MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM22108
BDBM22104
NameBDBM22108
Synonyms:7-{[2-(hydroxymethyl)azetidin-1-yl]methyl}-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one | Azetidine based compound, (+/-) 42
TypeSmall organic molecule
Emp. Form.C11H14N4O2
Mol. Mass.234.2545
SMILESOCC1CCN1Cc1c[nH]c2c1nc[nH]c2=O
Structure
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