| Reaction Details |
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 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
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| Ligand | BDBM22109 |
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| Substrate/Competitor | BDBM22104 |
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| Meas. Tech. | PNP Inhibition Assay |
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| pH | 7.7±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 0.5±0.04 nM |
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| Km | 5000±n/a nM |
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| Comments | Data was taken from J. Biol. Chem. 2005, 280, 30320-30328 |
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| Citation |  Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Purine nucleoside phosphorylase |
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| Name: | Purine nucleoside phosphorylase |
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| Synonyms: | Purine Nucleoside Phosphorylase (PNP) | pfPNP |
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| Type: | Enzyme |
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| Mol. Mass.: | 26857.85 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 245 |
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| Sequence: | MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFL
CVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHL
LIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAV
VEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKL
ATKYA
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| BDBM22109 |
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| BDBM22104 |
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| Name | BDBM22109 |
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| Synonyms: | 7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | 7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-1H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL1213653 | CHEMBL269864 | DADMe-ImmH,7 |
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| Type | n/a |
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| Emp. Form. | C12H16N4O3 |
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| Mol. Mass. | 264.2804 |
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| SMILES | OC[C@H]1CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O |r| |
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| Structure | 
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