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TargetAdenosylhomocysteine nucleosidase
LigandBDBM22110
Substrate/CompetitorBDBM22111
Meas. Tech.MTAP/MTAN Inhibition Assay
pH7±n/a
Temperature295.15±n/a K
Ki 150±12 nM
Km23000±n/a nM
Citation Evans, GBFurneaux, RHGreatrex, BMurkin, ASSchramm, VLTyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Adenosylhomocysteine nucleosidase
Name:Adenosylhomocysteine nucleosidase
Synonyms:5 -methylthioadenosine / S-adenosylhomocysteine nucleosidase | Methylthioadenosine Nucleosidase(MTAN)
Type:Enzyme
Mol. Mass.:24666.14
Organism:Streptococcus pneumoniae
Description:Q8DQ16
Residue:230
Sequence:
MKIGIIAAMPEELAYLVQHLDNTQEQVVLGNTYHTGTIASHEVVLVESGIGKVMSAMSVA
ILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDVTAFGYAYGQMAQQPLYFE
SDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAIKSHFPEVLAVEMEGAAIAQ
AAHTLNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRSAQVLLAFLKALD
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  Blast E-value cutoff:
BDBM22110
BDBM22111
NameBDBM22110
Synonyms:Azetidine based compound, 43 | [1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-3-[(methylsulfanyl)methyl]azetidin-3-yl]methanol
TypeSmall organic molecule
Emp. Form.C13H19N5OS
Mol. Mass.293.388
SMILESCSCC1(CO)CN(Cc2c[nH]c3c(N)ncnc23)C1
Structure
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