Reaction Details |
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Target | Adenosylhomocysteine nucleosidase |
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Ligand | BDBM22110 |
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Substrate/Competitor | BDBM22111 |
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Meas. Tech. | MTAP/MTAN Inhibition Assay |
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pH | 7±n/a |
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Temperature | 295.15±n/a K |
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Ki | 150±12 nM |
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Km | 23000±n/a nM |
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Citation | Evans, GB; Furneaux, RH; Greatrex, B; Murkin, AS; Schramm, VL; Tyler, PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem51:948-56 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Adenosylhomocysteine nucleosidase |
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Name: | Adenosylhomocysteine nucleosidase |
Synonyms: | 5 -methylthioadenosine / S-adenosylhomocysteine nucleosidase | Methylthioadenosine Nucleosidase(MTAN) |
Type: | Enzyme |
Mol. Mass.: | 24666.14 |
Organism: | Streptococcus pneumoniae |
Description: | Q8DQ16 |
Residue: | 230 |
Sequence: | MKIGIIAAMPEELAYLVQHLDNTQEQVVLGNTYHTGTIASHEVVLVESGIGKVMSAMSVA
ILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDVTAFGYAYGQMAQQPLYFE
SDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAIKSHFPEVLAVEMEGAAIAQ
AAHTLNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRSAQVLLAFLKALD
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BDBM22110 |
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BDBM22111 |
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Name | BDBM22110 |
Synonyms: | Azetidine based compound, 43 | [1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)-3-[(methylsulfanyl)methyl]azetidin-3-yl]methanol |
Type | Small organic molecule |
Emp. Form. | C13H19N5OS |
Mol. Mass. | 293.388 |
SMILES | CSCC1(CO)CN(Cc2c[nH]c3c(N)ncnc23)C1 |
Structure |
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