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TargetMethylthioadenosine Nucleosidase(MTAN)
LigandBDBM22112
Substrate/CompetitorBDBM22111
Meas. Tech.MTAP/MTAN Inhibition Assay
pH7±n/a
Temperature295.15±n/a K
Ki 84±6 nM
Km23000±n/a nM
Citation Evans GBFurneaux RHGreatrex BMurkin ASSchramm VLTyler PC Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. J Med Chem 51:948-56 (2008) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Methylthioadenosine Nucleosidase(MTAN)
Name:Methylthioadenosine Nucleosidase(MTAN)
Synonyms:5 -methylthioadenosine / S-adenosylhomocysteine nucleosidase
Type:Enzyme
Mol. Mass.:24666.14
Organism:Streptococcus pneumoniae
Description:Q8DQ16
Residue:230
Sequence:
MKIGIIAAMPEELAYLVQHLDNTQEQVVLGNTYHTGTIASHEVVLVESGIGKVMSAMSVA
ILADHFQVDALINTGSAGAVAEGIAVGDVVIADKLAYHDVDVTAFGYAYGQMAQQPLYFE
SDKTFVAQIQESLSQLDQNWHLGLIATGDSFVAGNDKIEAIKSHFPEVLAVEMEGAAIAQ
AAHTLNLPVLVIRAMSDNANHEANIFFDEFIIEAGRRSAQVLLAFLKALD
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  Blast E-value cutoff:
BDBM22112
BDBM22111
NameBDBM22112
Synonyms:7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine | Azetidine based compound, 44
TypeSmall organic molecule
Emp. Form.C12H17N5S
Mol. Mass.263.362
SMILESCSCC1CN(Cc2c[nH]c3c(N)ncnc23)C1
Structure
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