Ki Summary

Reaction Details

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Target

Substance-P receptor

Ligand

BDBM261487

Substrate/Competitor

n/a

Meas. Tech.

Receptor Binding Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

2.79±n/a nM

Comments

extracted

Citation

Shimizu, K; Ohno, K; Miyagi, T; Ueno, Y; Suzuki, H Cyclohexyl pyridine derivative US Patent US9708266 Publication Date 7/18/2017

More Info.:

Get all data from this article, Assay Method

Substance-P receptor

Name:

Substance-P receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

46254.43

Organism:

Homo sapiens (Human)

Description:

P25103

Residue:

407

Sequence:

MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS

BDBM261487

n/a

Name

BDBM261487

Synonyms:

US10011568, Ex. No. 10 | US9708266, 10

Type

Small organic molecule

Emp. Form.

C34H35F7N2O3

Mol. Mass.

652.6421

SMILES

CC(C1CCC(CC1)c1cc(c(cn1)N(C)C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)-c1ccc(F)cc1C)C(O)=O |(-8,-6.54,;-8,-5,;-6.67,-4.24,;-6.67,-2.7,;-5.33,-1.93,;-4,-2.7,;-4,-4.24,;-5.33,-5.01,;-2.67,-1.93,;-2.67,-.39,;-1.33,.38,;,-.39,;,-1.93,;-1.33,-2.7,;1.33,.38,;1.33,1.92,;2.67,-.39,;2.67,-1.93,;4,.38,;3.23,1.72,;4.77,1.72,;5.33,-.39,;5.33,-1.93,;6.67,-2.7,;8,-1.93,;8,-.39,;6.67,.38,;9.34,.38,;10.67,-.39,;9.34,1.92,;10.67,1.15,;6.67,-4.24,;8,-5.01,;5.33,-5.01,;6.67,-5.78,;-1.33,1.92,;,2.69,;,4.23,;-1.33,5,;-1.33,6.54,;-2.67,4.23,;-2.67,2.69,;-4,1.92,;-9.34,-4.23,;-10.67,-5,;-9.34,-2.69,)|

Structure