| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM371821 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Binding Assay for DDR1 |
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| IC50 | 12.7±n/a nM |
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| Citation |  Buettelmann, B; Kocer, B; Kuhn, B; Prunotto, M; Richter, H; Ritter, M; Rudolph, M; Satz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent US10239876 Publication Date 3/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 49303.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21728 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM371821 |
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| n/a |
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| Name | BDBM371821 |
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| Synonyms: | 2-[1-(3-Fluoro-phenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triaza-spiro[4.5]dec-3-yl]-N-(2,2,2-trifluoro-ethyl)-acetamide | US10239876, Example 2 | US10435407, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23F4N7O3 |
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| Mol. Mass. | 533.4781 |
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| SMILES | Fc1cccc(c1)N1CN(CC(=O)NCC(F)(F)F)C(=O)C11CCN(CC1)C(=O)c1cnc2[nH]ncc2c1 |
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| Structure | 
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