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TargetD(1A) dopamine receptor
LigandBDBM372102
Substrate/Competitorn/a
Meas. Tech.In Vitro Binding Assay for DDR1
IC50 12.9±n/a nM
Citation Buettelmann, BKocer, BKuhn, BPrunotto, MRichter, HRitter, MRudolph, MSatz, AL Triaza-spirodecanones as DDR1 inhibitors US Patent US10239876 Publication Date 3/26/2019
More Info.:Get all data from this article,  Assay Method
 
D(1A) dopamine receptor
Name:D(1A) dopamine receptor
Synonyms:DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:Enzyme
Mol. Mass.:49303.43
Organism:Homo sapiens (Human)
Description:P21728
Residue:446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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  Blast E-value cutoff:
BDBM372102
n/a
NameBDBM372102
Synonyms:2-(1-(3-Chlorophenyl)-4-oxo-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-3-yl)-N-(2,2,2-trifluoroethyl)acetamide | US10239876, Example 125 | US10435407, Example 125
TypeSmall organic molecule
Emp. Form.C24H23ClF3N7O3
Mol. Mass.549.933
SMILESFC(F)(F)CNC(=O)CN1CN(c2cccc(Cl)c2)C2(CCN(CC2)C(=O)c2cnc3[nH]ncc3c2)C1=O
Structure
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