Reaction Details |
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Target | Sphingosine 1-phosphate receptor 5 |
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Ligand | BDBM22220 |
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Substrate/Competitor | BDBM22202 |
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Meas. Tech. | S1P Receptor Binding Assay |
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Temperature | 298.15±n/a K |
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IC50 | 0.4±n/a nM |
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Comments | extracted |
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Citation | Li, Z; Chen, W; Hale, JJ; Lynch, CL; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Parent, SA; Bergstrom, J; Card, D; Forrest, M; Quackenbush, EJ; Wickham, LA; Vargas, H; Evans, RM; Rosen, H; Mandala, S Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem48:6169-73 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Sphingosine 1-phosphate receptor 5 |
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Name: | Sphingosine 1-phosphate receptor 5 |
Synonyms: | EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 41796.42 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 398 |
Sequence: | MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
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BDBM22220 |
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BDBM22202 |
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Name | BDBM22220 |
Synonyms: | 1,2,4-oxadiazole based compound, 37 | 1-{[4-(5-{4-[(1R)-3,3-difluorocyclopentyl]phenyl}-1,2,4-oxadiazol-3-yl)phenyl]methyl}azetidine-3-carboxylic acid |
Type | Small organic molecule |
Emp. Form. | C24H23F2N3O3 |
Mol. Mass. | 439.4545 |
SMILES | OC(=O)C1CN(Cc2ccc(cc2)-c2noc(n2)-c2ccc(cc2)[C@@H]2CCC(F)(F)C2)C1 |r| |
Structure |
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