Reaction Details |
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Target | Sphingosine 1-phosphate receptor 1 |
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Ligand | BDBM22221 |
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Substrate/Competitor | BDBM22202 |
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Meas. Tech. | S1P Receptor Binding Assay |
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Temperature | 298.15±n/a K |
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IC50 | 27±n/a nM |
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Comments | extracted |
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Citation | Li, Z; Chen, W; Hale, JJ; Lynch, CL; Mills, SG; Hajdu, R; Keohane, CA; Rosenbach, MJ; Milligan, JA; Shei, GJ; Chrebet, G; Parent, SA; Bergstrom, J; Card, D; Forrest, M; Quackenbush, EJ; Wickham, LA; Vargas, H; Evans, RM; Rosen, H; Mandala, S Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem48:6169-73 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Sphingosine 1-phosphate receptor 1 |
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Name: | Sphingosine 1-phosphate receptor 1 |
Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
Type: | Enzyme |
Mol. Mass.: | 42836.02 |
Organism: | Homo sapiens (Human) |
Description: | P21453 |
Residue: | 382 |
Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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BDBM22221 |
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BDBM22202 |
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Name | BDBM22221 |
Synonyms: | 1,3,4-oxadiazole based compound, 5 | 2-[5-(4-tert-butylphenyl)-1,3,4-oxadiazol-2-yl]aniline |
Type | Small organic molecule |
Emp. Form. | C18H19N3O |
Mol. Mass. | 293.363 |
SMILES | CC(C)(C)c1ccc(cc1)-c1nnc(o1)-c1ccccc1N |
Structure |
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