| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM340150 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Lck Enzyme Activity |
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| EC50 | >1000±n/a nM |
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| Citation |  Barf, TA; Jans, CG; de Man, AP; Oubrie, AA; Raaijmakers, HC; Rewinkel, JB; Sterrenburg, JG; Wijkmans, JC 4-imidazopyridazin-1-yl-benzamides as BTK inhibitors US Patent US10239883 Publication Date 3/26/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM340150 |
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| n/a |
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| Name | BDBM340150 |
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| Synonyms: | US10239883, Example 39 | US10934296, Example 39 | US9758524, Example 39 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22F3N7O2 |
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| Mol. Mass. | 521.4938 |
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| SMILES | CC#CC(=O)N(C)[C@@H](C)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12 |r| |
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| Structure | 
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