Reaction Details | |||
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Target | Gag-Pol polyprotein | ||
Ligand | BDBM372348 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | HIV Cell Culture Assay | ||
EC50 | 1.41±n/a nM | ||
Citation | Sit, S; Chen, Y; Chen, J; Swidorski, J; Venables, BL; Sin, N; Meanwell, NA; Regueiro-Ren, A; Hartz, RA; Xu, L; Liu, Z Triterpenoids with HIV maturation inhibitory activity US Patent US10245275 Publication Date 4/2/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Gag-Pol polyprotein | |||
Name: | Gag-Pol polyprotein | ||
Synonyms: | Capsid protein p24 | Gag-Pol polyprotein (Capsid Protein) | HIV-1 integrase (IN) WT | POL_HV1N5 | Reverse transcriptase (HIV-1 RT) | gag-pol | ||
Type: | Protein | ||
Mol. Mass.: | 161820.05 | ||
Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1) | ||
Description: | P12497 | ||
Residue: | 1435 | ||
Sequence: |
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BDBM372348 | |||
n/a | |||
Name | BDBM372348 | ||
Synonyms: | Preparation of (S)-4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-((1S,4S)-2,2-dioxido-2-thia-5-azabicyclo[2.2.1]heptan-5-yl)ethyl)amino)-5a,5b, 8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-(fluoromethyl)cyclohex-3-enecarboxylic acid | US10245275, Example 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C44H67FN2O4S | ||
Mol. Mass. | 739.077 | ||
SMILES | CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(C6=CC[C@@](CF)(CC6)C(O)=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)NCCN1C[C@@H]2C[C@@H]1CS2(=O)=O |r,t:18,20| | ||
Structure |