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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Gag-Pol polyprotein | ||
| Ligand | BDBM372358 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | HIV Cell Culture Assay | ||
| EC50 | <50±n/a nM | ||
| Citation |  Sit, S; Chen, Y; Chen, J; Swidorski, J; Venables, BL; Sin, N; Meanwell, NA; Regueiro-Ren, A; Hartz, RA; Xu, L; Liu, Z Triterpenoids with HIV maturation inhibitory activity US Patent US10245275 Publication Date 4/2/2019 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Gag-Pol polyprotein | |||
| Name: | Gag-Pol polyprotein | ||
| Synonyms: | Capsid protein p24 | Gag-Pol polyprotein (Capsid Protein) | HIV-1 integrase (IN) WT | POL_HV1N5 | Reverse transcriptase (HIV-1 RT) | gag-pol | ||
| Type: | Protein | ||
| Mol. Mass.: | 161820.05 | ||
| Organism: | Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1) | ||
| Description: | P12497 | ||
| Residue: | 1435 | ||
| Sequence: |
| ||
| BDBM372358 | |||
| n/a | |||
| Name | BDBM372358 | ||
| Synonyms: | Preparation of (1R)-4-((1R,3aS,5aR,5bR,7aR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(3-(ethoxycarbonyl)-1,1-dioxidothiomorpholino)ethyl)amino)-5a,5b, 8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11 b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)-1-(fluoromethyl)cyclohex-3-enecarboxylic acid | US10245275, Example 14 | US10245275, Example 15 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C46H71FN2O6S | ||
| Mol. Mass. | 799.129 | ||
| SMILES | CCOC(=O)C1CS(=O)(=O)CCN1CCN[C@]12CC[C@H]([C@@H]1[C@H]1CC[C@@H]3[C@@]4(C)CC=C(C5=CC[C@](CF)(CC5)C(O)=O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(C)=C |r,w:5.4,t:30,32| | ||
| Structure | 
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