| Reaction Details |
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 | Report a problem with these data |
| Target | Seed linoleate 13S-lipoxygenase-1 |
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| Ligand | BDBM22356 |
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| Substrate/Competitor | BDBM22231 |
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| Meas. Tech. | COX Inhibitor Screening Assay |
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| IC50 | 500±n/a nM |
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| Citation |  Rao, PN; Chen, QH; Knaus, EE Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. J Med Chem49:1668-83 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Seed linoleate 13S-lipoxygenase-1 |
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| Name: | Seed linoleate 13S-lipoxygenase-1 |
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| Synonyms: | 15-LOX | 15-Lipo-oxygenase (15-LO) | 15-lipo-oxygenase (SLO) | Arachidonic Acid 15- Lipoxygenase | L-1 | LOX1 | LOX1.1 | LOX1_SOYBN | Lipoxygenase (LOX) | Lipoxygenase (SLO) | Lipoxygenase-1 | Seed lipoxygenase-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 94365.66 |
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| Organism: | Glycine max (soybean) |
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| Description: | n/a |
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| Residue: | 839 |
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| Sequence: | MFSAGHKIKGTVVLMPKNELEVNPDGSAVDNLNAFLGRSVSLQLISATKADAHGKGKVGK
DTFLEGINTSLPTLGAGESAFNIHFEWDGSMGIPGAFYIKNYMQVEFFLKSLTLEAISNQ
GTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAPLVSYREEELKSLRGNGTGERKEY
DRIYDYDVYNDLGNPDKSEKLARPVLGGSSTFPYPRRGRTGRGPTVTDPNTEKQGEVFYV
PRDENLGHLKSKDALEIGTKSLSQIVQPAFESAFDLKSTPIEFHSFQDVHDLYEGGIKLP
RDVISTIIPLPVIKELYRTDGQHILKFPQPHVVQVSQSAWMTDEEFAREMIAGVNPCVIR
GLEEFPPKSNLDPAIYGDQSSKITADSLDLDGYTMDEALGSRRLFMLDYHDIFMPYVRQI
NQLNSAKTYATRTILFLREDGTLKPVAIELSLPHSAGDLSAAVSQVVLPAKEGVESTIWL
LAKAYVIVNDSCYHQLMSHWLNTHAAMEPFVIATHRHLSVLHPIYKLLTPHYRNNMNINA
LARQSLINANGIIETTFLPSKYSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSTPHG
VRLLIEDYPYAADGLEIWAAIKTWVQEYVPLYYARDDDVKNDSELQHWWKEAVEKGHGDL
KDKPWWPKLQTLEDLVEVCLIIIWIASALHAAVNFGQYPYGGLIMNRPTASRRLLPEKGT
PEYEEMINNHEKAYLRTITSKLPTLISLSVIEILSTHASDEVYLGQRDNPHWTSDSKALQ
AFQKFGNKLKEIEEKLVRRNNDPSLQGNRLGPVQLPYTLLYPSSEEGLTFRGIPNSISI
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| BDBM22356 |
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| BDBM22231 |
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| Name | BDBM22356 |
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| Synonyms: | 1,3-Diarylprop-2-yn-1-one, 13m | 1-(3-hydroxyphenyl)-3-(4-methanesulfonylphenyl)prop-2-yn-1-one | CHEMBL364739 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12O4S |
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| Mol. Mass. | 300.329 |
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| SMILES | CS(=O)(=O)c1ccc(cc1)C#CC(=O)c1cccc(O)c1 |
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| Structure | 
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