Reaction Details |
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Target | Nuclear receptor subfamily 5 group A member 2 |
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Ligand | BDBM22380 |
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Substrate/Competitor | Biotinylated TIF2 Peptide |
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Meas. Tech. | FRET Assay for LRH-1 |
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pH | 7.5±n/a |
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Temperature | 295.15±n/a K |
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EC50 | 1400±200 nM |
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Citation | Whitby, RJ; Dixon, S; Maloney, PR; Delerive, P; Goodwin, BJ; Parks, DJ; Willson, TM Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J Med Chem49:6652-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Nuclear receptor subfamily 5 group A member 2 |
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Name: | Nuclear receptor subfamily 5 group A member 2 |
Synonyms: | Alpha-1-fetoprotein transcription factor | B1-binding factor | B1F | CPF | CYP7A promoter-binding factor | FTF | Hepatocytic transcription factor | LRH-1 | Liver Receptor Homolog 1 | NR5A2 | NR5A2_HUMAN | Nuclear receptor subfamily 5 group A member 2 | hB1F | nuclear receptor subfamily 5 group A member 2 isoform 2 |
Type: | Nuclear Hormone Receptor |
Mol. Mass.: | 61341.37 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 541 |
Sequence: | MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQG
QMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRY
TCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQ
QKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPF
VTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPAS
IPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWA
RSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQA
GATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAA
LLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKR
A
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BDBM22380 |
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Biotinylated TIF2 Peptide |
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Name: | Biotinylated TIF2 Peptide |
Synonyms: | n/a |
Type: | Peptide |
Mol. Mass.: | 3740.71 |
Organism: | n/a |
Description: | A peptide derived from TIF2 amino acids 732-756. |
Residue: | 32 |
Sequence: | Biotin-QEPVSPKKKENALLRYLLDKDDTKD-CONH2
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