| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen-related receptor gamma |
|---|
| Ligand | BDBM22429 |
|---|
| Substrate/Competitor | BDBM20608 |
|---|
| Meas. Tech. | Radioligand Displacement Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Chao, EY; Collins, JL; Gaillard, S; Miller, AB; Wang, L; Orband-Miller, LA; Nolte, RT; McDonnell, DP; Willson, TM; Zuercher, WJ Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett16:821-4 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Estrogen-related receptor gamma |
|---|
| Name: | Estrogen-related receptor gamma |
|---|
| Synonyms: | ERR gamma-2 | ERR3 | ERR3_HUMAN | ERRG2 | ESRRG | Estrogen receptor-related protein 3 | Estrogen-Related Receptor, gamma | Estrogen-related receptor gamma | KIAA0832 | NR3B3 | Nuclear receptor subfamily 3 group B member 3 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 51305.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1501351 |
|---|
| Residue: | 458 |
|---|
| Sequence: | MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGG
SSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYML
NSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSC
QACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSH
LLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSL
LQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMK
LEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMT
LPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
|
|
|
|---|
| BDBM22429 |
|---|
| BDBM20608 |
|---|
| Name | BDBM22429 |
|---|
| Synonyms: | 4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-(methylsulfanyl)-2-phenylpent-1-en-1-yl]phenol | 4-hydroxytamoxifen (4-OHT) analog, 9 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H33NO2S |
|---|
| Mol. Mass. | 447.632 |
|---|
| SMILES | CSCCC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
