Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Genome polyprotein | ||
| Ligand | BDBM70637 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Pseudotyped HCV particle (HCVpp) reporter assay | ||
| EC50 | 9.0±n/a nM | ||
| Citation |  Bilotta, JA; Chen, Z; Chi, F; Chin, E; Ding, Q; Erickson, SD; Gabriel, SD; Jiang, N; Kocer, B; Mertz, E; Plancher, J; Weikert, RJ; Zhang, J; Zhang, Q Antiviral compounds US Patent US9693997 Publication Date 7/4/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Genome polyprotein | |||
| Name: | Genome polyprotein | ||
| Synonyms: | Dipeptidyl peptidase 4 (DPP4) | HCV NS3-NS4A Serine Proteinase | NS3 NS5B | NS3 Protease | NS3-4A Protease | NS3/4A Protein | NS3/4A protease | NS5B Polymerase | POLG_HCV77 | RNA polymerase (NS5B) | ||
| Type: | Protease Domain | ||
| Mol. Mass.: | 327221.49 | ||
| Organism: | Hepatitis C virus (HCV genotype 1a, isolate H) | ||
| Description: | P27958 | ||
| Residue: | 3011 | ||
| Sequence: |
| ||
| BDBM70637 | |||
| n/a | |||
| Name | BDBM70637 | ||
| Synonyms: | US9693997, 167 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24ClF3N6O4S | ||
| Mol. Mass. | 560.977 | ||
| SMILES | COc1cc(ccc1S(=O)(=O)N[C@H]1CC[C@H](O)CC1)-c1c(Cl)cc(Nc2n[nH]c(N)n2)cc1C(F)(F)F |r,wU:12.12,wD:15.16,$;;;;;;;;;;;HN;;;;;;;;;;;;;HN;;;;;;;;;;;;$,(3.65,2.7,;3.65,1.16,;2.31,.39,;.98,1.15,;-.35,.38,;-.35,-1.15,;.98,-1.92,;2.31,-1.15,;3.65,-1.92,;3.65,-3.46,;2.31,-2.69,;4.98,-1.15,;6.47,-1.55,;7.56,-.46,;9.05,-.86,;9.44,-2.35,;10.93,-2.75,;8.36,-3.44,;6.87,-3.04,;-1.69,1.15,;-1.69,2.69,;-.35,3.46,;-3.02,3.46,;-4.35,2.69,;-5.69,3.46,;-7.02,2.69,;-7.02,1.15,;-8.49,.68,;-9.39,1.92,;-10.93,1.92,;-8.49,3.17,;-4.35,1.15,;-3.02,.38,;-3.02,-1.16,;-4.35,-1.93,;-4.51,-.76,;-1.69,-1.93,)| | ||
| Structure | 
| ||