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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Genome polyprotein | ||
| Ligand | BDBM70646 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Pseudotyped HCV particle (HCVpp) reporter assay | ||
| EC50 | 19±n/a nM | ||
| Citation |  Bilotta, JA; Chen, Z; Chi, F; Chin, E; Ding, Q; Erickson, SD; Gabriel, SD; Jiang, N; Kocer, B; Mertz, E; Plancher, J; Weikert, RJ; Zhang, J; Zhang, Q Antiviral compounds US Patent US9693997 Publication Date 7/4/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Genome polyprotein | |||
| Name: | Genome polyprotein | ||
| Synonyms: | Dipeptidyl peptidase 4 (DPP4) | HCV NS3-NS4A Serine Proteinase | NS3 NS5B | NS3 Protease | NS3-4A Protease | NS3/4A Protein | NS3/4A protease | NS5B Polymerase | POLG_HCV77 | RNA polymerase (NS5B) | ||
| Type: | Protease Domain | ||
| Mol. Mass.: | 327221.49 | ||
| Organism: | Hepatitis C virus (HCV genotype 1a, isolate H) | ||
| Description: | P27958 | ||
| Residue: | 3011 | ||
| Sequence: |
| ||
| BDBM70646 | |||
| n/a | |||
| Name | BDBM70646 | ||
| Synonyms: | US9693997, 173 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H18ClF3N6O3S | ||
| Mol. Mass. | 502.898 | ||
| SMILES | Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N[C@H]3C[C@H](O)C3)c(c2)C(F)(F)F)n[nH]1 |r,wU:22.23,wD:20.20,$;;;;HN;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,(-9.04,3.89,;-7.5,3.89,;-6.6,5.14,;-5.13,4.66,;-3.8,5.43,;-2.47,4.66,;-1.13,5.43,;.2,4.66,;1.53,5.43,;.2,3.12,;1.53,2.35,;1.53,.81,;2.87,.04,;4.2,.81,;4.2,2.35,;2.87,3.12,;5.54,.04,;6.87,.81,;5.54,-1.5,;7.31,-.35,;7.71,-1.84,;6.94,-3.18,;8.27,-3.95,;8.67,-5.43,;9.04,-2.61,;-1.13,2.35,;-2.47,3.12,;-1.13,.81,;.2,.04,;-2.47,.04,;-2.62,1.21,;-5.13,3.12,;-6.6,2.65,)| | ||
| Structure | 
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