| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM22538 |
|---|
| Substrate/Competitor | BDBM22530 |
|---|
| Meas. Tech. | H3R Radioligand Binding Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| Ki | 2±0.1 nM |
|---|
| Citation |  Wijtmans, M; Celanire, S; Snip, E; Gillard, MR; Gelens, E; Collart, PP; Venhuis, BJ; Christophe, B; Hulscher, S; van der Goot, H; Lebon, F; Timmerman, H; Bakker, RA; Lallemand, BI; Leurs, R; Talaga, PE; de Esch, IJ 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. J Med Chem51:2944-53 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48691.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
|---|
| BDBM22538 |
|---|
| BDBM22530 |
|---|
| Name | BDBM22538 |
|---|
| Synonyms: | 4-Benzyl-1H-imidazole derivative, 19 | 4-{[3-(2-phenylethynyl)phenyl]methyl}-1H-imidazole |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H14N2 |
|---|
| Mol. Mass. | 258.3172 |
|---|
| SMILES | C(c1cnc[nH]1)c1cccc(c1)C#Cc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
