Reaction Details |
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Target | Histamine H3 receptor |
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Ligand | BDBM22549 |
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Substrate/Competitor | BDBM22530 |
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Meas. Tech. | H3R Radioligand Binding Assay |
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pH | 7.4±n/a |
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Temperature | 298.15±n/a K |
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Ki | 40±8 nM |
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Citation | Wijtmans, M; Celanire, S; Snip, E; Gillard, MR; Gelens, E; Collart, PP; Venhuis, BJ; Christophe, B; Hulscher, S; van der Goot, H; Lebon, F; Timmerman, H; Bakker, RA; Lallemand, BI; Leurs, R; Talaga, PE; de Esch, IJ 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. J Med Chem51:2944-53 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Histamine H3 receptor |
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Name: | Histamine H3 receptor |
Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 48691.47 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
Residue: | 445 |
Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM22549 |
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BDBM22530 |
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Name | BDBM22549 |
Synonyms: | 2-[3-(1H-imidazol-4-ylmethyl)phenyl]-3-oxa-1-azaspiro[4.4]non-1-ene | 4-Benzyl-1H-imidazole derivative, 27 |
Type | Small organic molecule |
Emp. Form. | C17H19N3O |
Mol. Mass. | 281.3523 |
SMILES | C(c1cnc[nH]1)c1cccc(c1)C1=NC2(CCCC2)CO1 |t:14| |
Structure |
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