| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional purine biosynthesis protein ATIC |
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| Ligand | BDBM22585 |
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| Substrate/Competitor | BDBM22579 |
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| Meas. Tech. | AICAR Tfase Inhibition Assay |
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| pH | 7.5±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | >100000±n/a nM |
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| Citation |  Xu, L; Chong, Y; Hwang, I; D'Onofrio, A; Amore, K; Beardsley, GP; Li, C; Olson, AJ; Boger, DL; Wilson, IA Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem282:13033-46 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Bifunctional purine biosynthesis protein ATIC |
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| Name: | Bifunctional purine biosynthesis protein ATIC |
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| Synonyms: | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase | 5-aminoimidazole-4-carboxamide-ribonucleotide transformylase | AICAR Tfase | AICAR transformylase | ATIC | Aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) | Bifunctional purine biosynthesis protein PURH | IMP Cyclohydrolase (IMPCH) | IMP cyclohydrolase | IMP synthetase | Inosinicase | PUR9_HUMAN | PURH | Phosphoribosylaminoimidazolecarboxamide formyltransferase | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Protein |
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| Mol. Mass.: | 64616.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31939 |
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| Residue: | 592 |
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| Sequence: | MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA
VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT
HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL
CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS
AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG
NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV
ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT
GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA
FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
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| BDBM22585 |
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| BDBM22579 |
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| Name | BDBM22585 |
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| Synonyms: | 1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadiazine-2,2,4-trione | Heterocycle, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C4H4N4O3S |
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| Mol. Mass. | 188.165 |
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| SMILES | O=C1NS(=O)(=O)Nc2nc[nH]c12 |
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| Structure | 
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