| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [64-515] |
|---|
| Ligand | BDBM230810 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Caliper Assay |
|---|
| IC50 | 0.200±n/a nM |
|---|
| Citation |  Furet, P; Grotzfeld, RM; Jahnke, W; Jones, D; Manley, PW; Marzinzik, A; Pelle, XF; Salem, B; Schoepfer, J Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9896444 Publication Date 2/20/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase ABL1 [64-515] |
|---|
| Name: | Tyrosine-protein kinase ABL1 [64-515] |
|---|
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 51539.77 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 64-515 |
|---|
| Residue: | 452 |
|---|
| Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
|
|
|
|---|
| BDBM230810 |
|---|
| n/a |
|---|
| Name | BDBM230810 |
|---|
| Synonyms: | US9340537, 64 | US9896444, Example 64 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17ClF2N6O2 |
|---|
| Mol. Mass. | 434.827 |
|---|
| SMILES | NC1CN(C1)c1ncc(cc1-c1ccn[nH]1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
