| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [64-515] |
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| Ligand | BDBM230815 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Caliper Assay |
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| IC50 | 0.200±n/a nM |
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| Citation |  Furet, P; Grotzfeld, RM; Jahnke, W; Jones, D; Manley, PW; Marzinzik, A; Pelle, XF; Salem, B; Schoepfer, J Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent US9896444 Publication Date 2/20/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Tyrosine-protein kinase ABL1 [64-515] |
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| Name: | Tyrosine-protein kinase ABL1 [64-515] |
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| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 51539.77 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 64-515 |
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| Residue: | 452 |
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| Sequence: | NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLE
KHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGK
LYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDIT
MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLG
VCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRD
LAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVW
AFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDR
PSFAEIHQAFETMFQESSISDEVEKELGKQGV
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| BDBM230815 |
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| n/a |
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| Name | BDBM230815 |
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| Synonyms: | US9340537, 69 | US9896444, Example 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18F3N5O3 |
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| Mol. Mass. | 433.3838 |
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| SMILES | CC1(O)CN(C1)c1ncc(cc1-c1ncc[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |
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| Structure | 
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