Reaction Details |
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Target | Adenosine deaminase |
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Ligand | BDBM22917 |
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Substrate/Competitor | BDBM14487 |
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Meas. Tech. | ADA Inhibition Assay |
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pH | 7.4±n/a |
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Temperature | 295.15±n/a K |
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Ki | 5900±n/a nM |
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Citation | Terasaka, T; Nakanishi, I; Nakamura, K; Eikyu, Y; Kinoshita, T; Nishio, N; Sato, A; Kuno, M; Seki, N; Sakane, K Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors. Bioorg Med Chem Lett13:1115-8 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Adenosine deaminase |
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Name: | Adenosine deaminase |
Synonyms: | ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase |
Type: | Enzyme |
Mol. Mass.: | 40759.44 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain. |
Residue: | 363 |
Sequence: | MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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BDBM22917 |
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BDBM14487 |
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Name | BDBM22917 |
Synonyms: | 1-(1-hydroxy-4-phenylbutan-2-yl)-1H-imidazole-4-carboxamide | CHEMBL13696 | FR221647 | imidazole-4-carboxamide derivative, 1 |
Type | Small organic molecule |
Emp. Form. | C14H17N3O2 |
Mol. Mass. | 259.3037 |
SMILES | NC(=O)c1cn(cn1)C(CO)CCc1ccccc1 |
Structure |
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