| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine deaminase |
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| Ligand | BDBM22932 |
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| Substrate/Competitor | BDBM14487 |
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| Meas. Tech. | ADA Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 91±n/a nM |
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| Citation |  Terasaka, T; Kinoshita, T; Kuno, M; Seki, N; Tanaka, K; Nakanishi, I Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors. J Med Chem47:3730-43 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Adenosine deaminase |
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| Name: | Adenosine deaminase |
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| Synonyms: | ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 40759.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain. |
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| Residue: | 363 |
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| Sequence: | MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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| BDBM22932 |
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| BDBM14487 |
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| Name | BDBM22932 |
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| Synonyms: | 1-[(2R)-1-hydroxy-4-[6-(6-phenylhexanamido)-1H-indol-1-yl]butan-2-yl]-1H-imidazole-4-carboxamide | Hybrid compound 1(FR235999) derivative, 4f |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33N5O3 |
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| Mol. Mass. | 487.5933 |
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| SMILES | NC(=O)c1cn(cn1)[C@@H](CO)CCn1ccc2ccc(NC(=O)CCCCCc3ccccc3)cc12 |r| |
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| Structure | 
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