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TargetAdenosine deaminase
LigandBDBM22941
Substrate/CompetitorBDBM14487
Meas. Tech.ADA Inhibition Assay
pH7.4±n/a
Temperature295.15±n/a K
Ki 240±n/a nM
Citation Terasaka, TKinoshita, TKuno, MSeki, NTanaka, KNakanishi, I Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors. J Med Chem47:3730-43 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Adenosine deaminase
Name:Adenosine deaminase
Synonyms:ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase
Type:Enzyme
Mol. Mass.:40759.44
Organism:Homo sapiens (Human)
Description:Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain.
Residue:363
Sequence:
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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  Blast E-value cutoff:
BDBM22941
BDBM14487
NameBDBM22941
Synonyms:1-[(2R)-4-(6-butoxy-1H-indol-1-yl)-1-hydroxybutan-2-yl]-1H-imidazole-4-carboxamide | Hybrid compound 1(FR235999) derivative, 6d
TypeSmall organic molecule
Emp. Form.C20H26N4O3
Mol. Mass.370.4454
SMILESCCCCOc1ccc2ccn(CC[C@H](CO)n3cnc(c3)C(N)=O)c2c1 |r|
Structure
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