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TargetAdenosine deaminase
LigandBDBM22920
Substrate/CompetitorBDBM14487
Meas. Tech.ADA Inhibition Assay
pH7.4±n/a
Temperature295.15±n/a K
Ki 7.7±n/a nM
Citation Terasaka, TOkumura, HTsuji, KKato, TNakanishi, IKinoshita, TKato, YKuno, MSeki, NNaoe, YInoue, TTanaka, KNakamura, K Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors. J Med Chem47:2728-31 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Adenosine deaminase
Name:Adenosine deaminase
Synonyms:ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase
Type:Enzyme
Mol. Mass.:40759.44
Organism:Homo sapiens (Human)
Description:Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain.
Residue:363
Sequence:
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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  Blast E-value cutoff:
BDBM22920
BDBM14487
NameBDBM22920
Synonyms:1-[(2R)-1-hydroxy-4-{6-[3-(1-methyl-1H-1,3-benzodiazol-2-yl)propanamido]-1H-indol-1-yl}butan-2-yl]-1H-imidazole-4-carboxamide | CHEMBL93280 | FR235999
TypeSmall organic molecule
Emp. Form.C27H29N7O3
Mol. Mass.499.5643
SMILESCn1c(CCC(=O)Nc2ccc3ccn(CC[C@H](CO)n4cnc(c4)C(N)=O)c3c2)nc2ccccc12 |r|
Structure
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