| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine deaminase |
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| Ligand | BDBM22950 |
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| Substrate/Competitor | BDBM14487 |
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| Meas. Tech. | ADA Inhibition Assay |
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| pH | 7.4±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 9.8±n/a nM |
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| Citation |  Terasaka, T; Okumura, H; Tsuji, K; Kato, T; Nakanishi, I; Kinoshita, T; Kato, Y; Kuno, M; Seki, N; Naoe, Y; Inoue, T; Tanaka, K; Nakamura, K Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors. J Med Chem47:2728-31 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Adenosine deaminase |
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| Name: | Adenosine deaminase |
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| Synonyms: | ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 40759.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain. |
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| Residue: | 363 |
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| Sequence: | MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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| BDBM22950 |
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| BDBM14487 |
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| Name | BDBM22950 |
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| Synonyms: | 1-[(3R,4S)-4-hydroxy-1-(naphthalen-2-yloxy)pentan-3-yl]-1H-imidazole-4-carboxamide | imidazole-4-carboxamide analogue, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21N3O3 |
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| Mol. Mass. | 339.3883 |
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| SMILES | C[C@H](O)[C@@H](CCOc1ccc2ccccc2c1)n1cnc(c1)C(N)=O |r| |
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| Structure | 
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