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TargetFatty Acid Amide Hydrolase
LigandBDBM23067
Substrate/CompetitorBDBM23028
Meas. Tech.FAAH Inhibition Assay
Temperature298.15±n/a K
Ki 6.7±n/a nM
IC50 30±n/a nM
Commentsextracted
Citation Hardouin CKelso MJRomero FARayl TJLeung DHwang ICravatt BFBoger DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem 50:3359-68 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Fatty Acid Amide Hydrolase
Name:DNA Ligase I
Synonyms:ATP-dependent DNA ligase | Polydeoxyribonucleotide synthase [ATP]
Type:Enzyme
Mol. Mass.:101721.76
Organism:Homo sapiens (Human)
Description:n/a
Residue:919
Sequence:
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
SQIQNQQGEDSGSDPEDTY
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  Blast E-value cutoff:
BDBM23067
BDBM23028
NameBDBM23067
Synonyms:7-(4-hexylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one | alpha-ketooxazole, 5nn
TypeSmall organic molecule
Emp. Form.C27H34N2O2
Mol. Mass.418.5711
SMILESCCCCCCc1ccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)cc1
Structure
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