Reaction Details |
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Target | Carboxylic ester hydrolase |
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Ligand | BDBM23069 |
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Substrate/Competitor | BDBM23139 |
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Meas. Tech. | TGH Inhibition Assay |
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IC50 | 8000±n/a nM |
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Citation | Hardouin, C; Kelso, MJ; Romero, FA; Rayl, TJ; Leung, D; Hwang, I; Cravatt, BF; Boger, DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem50:3359-68 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Carboxylic ester hydrolase |
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Name: | Carboxylic ester hydrolase |
Synonyms: | Carboxylesterase 3 precursor | TGH | Triacylglycerol Hydrolase |
Type: | Homotrimer; type-B carboxylesterase/lipase family |
Mol. Mass.: | 61960.20 |
Organism: | Homo sapiens (Human) |
Description: | Q8TDZ9 |
Residue: | 565 |
Sequence: | MWLFDLVLTSLATSMAWGYPSLPPVVDTVQGKVLGKYVSLEGFAQPVAVFLGVPFAKPPL
GPLRFAPPQAAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKDNIPLKFSEDCLYLN
IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHGRGNWGHLDQLAALRWVQENIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTAALVKKDMKDTAQQIAVFAGCKSTTSAVLVHCLRQKTEDELLEVSLKL
KFFTLDLLGDPRESYPFLPTVVDGVLLPKMPQEILAEKKFNSVPYIIGINKQEFGWLLPM
MMGYPLSEDKLDQKTASSLLWKSYPIANIPEELTPLASEKYLGGTDDPVKKKALFLDMLG
DVVFGVPSVTVARHHRDAGAPTYMYEFQYHPSFSSDMKPQTVVGDHGDELFSVFGAPFLK
GGASEEEIRLSKMMMKLWANFARSGNPMGKGCSSWPAYDQKEGYLQIGIPTQPAQKLKSK
EMAFWTELLAKRAAEKLSPTEHVEL
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BDBM23069 |
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BDBM23139 |
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Name | BDBM23069 |
Synonyms: | 3-[4-(benzyloxy)phenyl]-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]propan-1-one | alpha-ketooxazole, 11a |
Type | Small organic molecule |
Emp. Form. | C24H20N2O3 |
Mol. Mass. | 384.4272 |
SMILES | O=C(CCc1ccc(OCc2ccccc2)cc1)c1ncc(o1)-c1ccccn1 |
Structure |
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