Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCarboxylic ester hydrolase
LigandBDBM23069
Substrate/CompetitorBDBM23139
Meas. Tech.TGH Inhibition Assay
IC50 8000±n/a nM
Citation Hardouin, CKelso, MJRomero, FARayl, TJLeung, DHwang, ICravatt, BFBoger, DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem50:3359-68 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Carboxylic ester hydrolase
Name:Carboxylic ester hydrolase
Synonyms:Carboxylesterase 3 precursor | TGH | Triacylglycerol Hydrolase
Type:Homotrimer; type-B carboxylesterase/lipase family
Mol. Mass.:61960.20
Organism:Homo sapiens (Human)
Description:Q8TDZ9
Residue:565
Sequence:
MWLFDLVLTSLATSMAWGYPSLPPVVDTVQGKVLGKYVSLEGFAQPVAVFLGVPFAKPPL
GPLRFAPPQAAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKDNIPLKFSEDCLYLN
IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHGRGNWGHLDQLAALRWVQENIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTAALVKKDMKDTAQQIAVFAGCKSTTSAVLVHCLRQKTEDELLEVSLKL
KFFTLDLLGDPRESYPFLPTVVDGVLLPKMPQEILAEKKFNSVPYIIGINKQEFGWLLPM
MMGYPLSEDKLDQKTASSLLWKSYPIANIPEELTPLASEKYLGGTDDPVKKKALFLDMLG
DVVFGVPSVTVARHHRDAGAPTYMYEFQYHPSFSSDMKPQTVVGDHGDELFSVFGAPFLK
GGASEEEIRLSKMMMKLWANFARSGNPMGKGCSSWPAYDQKEGYLQIGIPTQPAQKLKSK
EMAFWTELLAKRAAEKLSPTEHVEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM23069
BDBM23139
NameBDBM23069
Synonyms:3-[4-(benzyloxy)phenyl]-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]propan-1-one | alpha-ketooxazole, 11a
TypeSmall organic molecule
Emp. Form.C24H20N2O3
Mol. Mass.384.4272
SMILESO=C(CCc1ccc(OCc2ccccc2)cc1)c1ncc(o1)-c1ccccn1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: