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TargetTriacylglycerol Hydrolase
LigandBDBM23032
Substrate/CompetitorBDBM23139
Meas. Tech.FAAH Inhibition Assay
Temperature298.15±n/a K
IC50 1000±n/a nM
Commentsextracted
Citation Hardouin CKelso MJRomero FARayl TJLeung DHwang ICravatt BFBoger DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem 50:3359-68 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Triacylglycerol Hydrolase
Name:Triacylglycerol Hydrolase
Synonyms:Carboxylesterase 3 precursor | TGH
Type:Homotrimer; type-B carboxylesterase/lipase family
Mol. Mass.:61960.20
Organism:Homo sapiens (Human)
Description:Q8TDZ9
Residue:565
Sequence:
MWLFDLVLTSLATSMAWGYPSLPPVVDTVQGKVLGKYVSLEGFAQPVAVFLGVPFAKPPL
GPLRFAPPQAAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKDNIPLKFSEDCLYLN
IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHGRGNWGHLDQLAALRWVQENIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTAALVKKDMKDTAQQIAVFAGCKSTTSAVLVHCLRQKTEDELLEVSLKL
KFFTLDLLGDPRESYPFLPTVVDGVLLPKMPQEILAEKKFNSVPYIIGINKQEFGWLLPM
MMGYPLSEDKLDQKTASSLLWKSYPIANIPEELTPLASEKYLGGTDDPVKKKALFLDMLG
DVVFGVPSVTVARHHRDAGAPTYMYEFQYHPSFSSDMKPQTVVGDHGDELFSVFGAPFLK
GGASEEEIRLSKMMMKLWANFARSGNPMGKGCSSWPAYDQKEGYLQIGIPTQPAQKLKSK
EMAFWTELLAKRAAEKLSPTEHVEL
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  Blast E-value cutoff:
BDBM23032
BDBM23139
NameBDBM23032
Synonyms:7-(pyridin-2-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one | alpha-ketooxazole, 5e
TypeSmall organic molecule
Emp. Form.C20H21N3O2
Mol. Mass.335.3996
SMILESO=C(CCCCCCc1ccccn1)c1ncc(o1)-c1ccccn1
Structure
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