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TargetTriacylglycerol Hydrolase
LigandBDBM23057
Substrate/CompetitorBDBM23139
Meas. Tech.FAAH Inhibition Assay
Temperature298.15±n/a K
IC50 6000±n/a nM
Commentsextracted
Citation Hardouin CKelso MJRomero FARayl TJLeung DHwang ICravatt BFBoger DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem 50:3359-68 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Triacylglycerol Hydrolase
Name:Triacylglycerol Hydrolase
Synonyms:Carboxylesterase 3 precursor | TGH
Type:Homotrimer; type-B carboxylesterase/lipase family
Mol. Mass.:61960.20
Organism:Homo sapiens (Human)
Description:Q8TDZ9
Residue:565
Sequence:
MWLFDLVLTSLATSMAWGYPSLPPVVDTVQGKVLGKYVSLEGFAQPVAVFLGVPFAKPPL
GPLRFAPPQAAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKDNIPLKFSEDCLYLN
IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHGRGNWGHLDQLAALRWVQENIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTAALVKKDMKDTAQQIAVFAGCKSTTSAVLVHCLRQKTEDELLEVSLKL
KFFTLDLLGDPRESYPFLPTVVDGVLLPKMPQEILAEKKFNSVPYIIGINKQEFGWLLPM
MMGYPLSEDKLDQKTASSLLWKSYPIANIPEELTPLASEKYLGGTDDPVKKKALFLDMLG
DVVFGVPSVTVARHHRDAGAPTYMYEFQYHPSFSSDMKPQTVVGDHGDELFSVFGAPFLK
GGASEEEIRLSKMMMKLWANFARSGNPMGKGCSSWPAYDQKEGYLQIGIPTQPAQKLKSK
EMAFWTELLAKRAAEKLSPTEHVEL
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  Blast E-value cutoff:
BDBM23057
BDBM23139
NameBDBM23057
Synonyms:alpha-ketooxazole, 5cc | methyl 4-{7-oxo-7-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptyl}benzoate
TypeSmall organic molecule
Emp. Form.C23H24N2O4
Mol. Mass.392.4477
SMILESCOC(=O)c1ccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)cc1
Structure
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