| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxylic ester hydrolase |
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| Ligand | BDBM23061 |
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| Substrate/Competitor | BDBM23139 |
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| Meas. Tech. | FAAH Inhibition Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 500±n/a nM |
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| Comments | extracted |
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| Citation |  Hardouin, C; Kelso, MJ; Romero, FA; Rayl, TJ; Leung, D; Hwang, I; Cravatt, BF; Boger, DL Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. J Med Chem50:3359-68 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Carboxylic ester hydrolase |
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| Name: | Carboxylic ester hydrolase |
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| Synonyms: | Carboxylesterase 3 precursor | TGH | Triacylglycerol Hydrolase |
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| Type: | Homotrimer; type-B carboxylesterase/lipase family |
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| Mol. Mass.: | 61960.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TDZ9 |
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| Residue: | 565 |
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| Sequence: | MWLFDLVLTSLATSMAWGYPSLPPVVDTVQGKVLGKYVSLEGFAQPVAVFLGVPFAKPPL
GPLRFAPPQAAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKDNIPLKFSEDCLYLN
IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHGRGNWGHLDQLAALRWVQENIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTAALVKKDMKDTAQQIAVFAGCKSTTSAVLVHCLRQKTEDELLEVSLKL
KFFTLDLLGDPRESYPFLPTVVDGVLLPKMPQEILAEKKFNSVPYIIGINKQEFGWLLPM
MMGYPLSEDKLDQKTASSLLWKSYPIANIPEELTPLASEKYLGGTDDPVKKKALFLDMLG
DVVFGVPSVTVARHHRDAGAPTYMYEFQYHPSFSSDMKPQTVVGDHGDELFSVFGAPFLK
GGASEEEIRLSKMMMKLWANFARSGNPMGKGCSSWPAYDQKEGYLQIGIPTQPAQKLKSK
EMAFWTELLAKRAAEKLSPTEHVEL
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| BDBM23061 |
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| BDBM23139 |
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| Name | BDBM23061 |
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| Synonyms: | 7-(3-chlorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one | CHEMBL388599 | alpha-ketooxazole, 5hh |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClN2O2 |
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| Mol. Mass. | 368.857 |
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| SMILES | Clc1cccc(CCCCCCC(=O)c2ncc(o2)-c2ccccn2)c1 |
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| Structure | 
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