Reaction Details |
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Target | Glycogen phosphorylase, muscle form |
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Ligand | BDBM23197 |
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Substrate/Competitor | BDBM23188 |
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Meas. Tech. | Enzyme Inhibition Assay |
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pH | 7.2±n/a |
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Temperature | 295.15±n/a K |
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IC50 | 9000±n/a nM |
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Citation | Wen, X; Sun, H; Liu, J; Cheng, K; Zhang, P; Zhang, L; Hao, J; Zhang, L; Ni, P; Zographos, SE; Leonidas, DD; Alexacou, KM; Gimisis, T; Hayes, JM; Oikonomakos, NG Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships, and X-ray Crystallographic Studies. J Med Chem51:3540-54 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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Glycogen phosphorylase, muscle form |
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Name: | Glycogen phosphorylase, muscle form |
Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
Type: | Enzyme |
Mol. Mass.: | 97296.32 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
Residue: | 843 |
Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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BDBM23197 |
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BDBM23188 |
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Name | BDBM23197 |
Synonyms: | (1S,2R,4aS,6aS,6bR,10S,12aR,12bR,14bS)-10-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | US11660306, Example Ursolic acid | Ursolic Acid, 10 | Ursolic acid (UA) | pentacyclic triterpene compound 10 |
Type | Terpene |
Emp. Form. | C30H48O3 |
Mol. Mass. | 456.7003 |
SMILES | [H][C@@]12[C@@H](C)[C@H](C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)C3CC[C@@]12C)C(O)=O |r,t:15| |
Structure |
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