| Reaction Details |
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 | Report a problem with these data |
| Target | L-lactate dehydrogenase |
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| Ligand | BDBM23226 |
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| Substrate/Competitor | BDBM19473 |
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| Meas. Tech. | Lactate Dehydrogenase Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 191000±1370 nM |
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| Citation |  Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| L-lactate dehydrogenase |
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| Name: | L-lactate dehydrogenase |
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| Synonyms: | L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH |
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| Type: | Oxidoreductase |
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| Mol. Mass.: | 34111.90 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 316 |
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| Sequence: | MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCK
VSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNA
FIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVG
AHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPA
AAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKA
KFDEAIAETKRMKALA
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| BDBM23226 |
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| BDBM19473 |
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| Name | BDBM23226 |
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| Synonyms: | 7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]ethoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 4 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17NO10 |
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| Mol. Mass. | 443.3604 |
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| SMILES | COc1cc(CCOc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O |
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| Structure | 
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