Reaction Details |
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Target | L-lactate dehydrogenase |
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Ligand | BDBM23228 |
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Substrate/Competitor | BDBM19473 |
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Meas. Tech. | Lactate Dehydrogenase Inhibition Assay |
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pH | 7±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 8250±500 nM |
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Citation | Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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L-lactate dehydrogenase |
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Name: | L-lactate dehydrogenase |
Synonyms: | L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH |
Type: | Oxidoreductase |
Mol. Mass.: | 34111.90 |
Organism: | Plasmodium falciparum |
Description: | n/a |
Residue: | 316 |
Sequence: | MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCK
VSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNA
FIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVG
AHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPA
AAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKA
KFDEAIAETKRMKALA
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BDBM23228 |
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BDBM19473 |
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Name | BDBM23228 |
Synonyms: | Oxamic acid derivative, 6 | [(2-cyano-4-{2-[(5-hydroxy-2-{[(4-methoxyphenyl)methyl]carbamoyl}-4-oxo-4H-chromen-7-yl)oxy]ethyl}phenyl)carbamoyl]formic acid |
Type | Small organic molecule |
Emp. Form. | C29H23N3O9 |
Mol. Mass. | 557.5076 |
SMILES | COc1ccc(CNC(=O)c2cc(=O)c3c(O)cc(OCCc4ccc(NC(=O)C(O)=O)c(c4)C#N)cc3o2)cc1 |
Structure |
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