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TargetL-lactate dehydrogenase
LigandBDBM23229
Substrate/CompetitorBDBM19473
Meas. Tech.Lactate Dehydrogenase Inhibition Assay
pH7±n/a
Temperature298.15±n/a K
IC50 1750±300 nM
Citation Choi, SRPradhan, AHammond, NLChittiboyina, AGTekwani, BLAvery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
L-lactate dehydrogenase
Name:L-lactate dehydrogenase
Synonyms:L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH
Type:Oxidoreductase
Mol. Mass.:34111.90
Organism:Plasmodium falciparum
Description:n/a
Residue:316
Sequence:
MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCK
VSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNA
FIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVG
AHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPA
AAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKA
KFDEAIAETKRMKALA
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  Blast E-value cutoff:
BDBM23229
BDBM19473
NameBDBM23229
Synonyms:Oxamic acid derivative, 7 | [(4-{2-[(5-hydroxy-2-{[(4-methoxyphenyl)methyl]carbamoyl}-4-oxo-4H-chromen-7-yl)oxy]ethyl}-2-methoxyphenyl)carbamoyl]formic acid
TypeSmall organic molecule
Emp. Form.C29H26N2O10
Mol. Mass.562.5241
SMILESCOc1ccc(CNC(=O)c2cc(=O)c3c(O)cc(OCCc4ccc(NC(=O)C(O)=O)c(OC)c4)cc3o2)cc1
Structure
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