Reaction Details |
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Target | Malate dehydrogenase, mitochondrial |
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Ligand | BDBM23229 |
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Substrate/Competitor | BDBM23230 |
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Meas. Tech. | Lactate Dehydrogenase Inhibition Assay |
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IC50 | 390±n/a nM |
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Citation | Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Malate dehydrogenase, mitochondrial |
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Name: | Malate dehydrogenase, mitochondrial |
Synonyms: | MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial |
Type: | Oxidoreductase; homodimer |
Mol. Mass.: | 35493.48 |
Organism: | Sus scrofa (pig) |
Description: | Porcine heart mitochondria. |
Residue: | 337 |
Sequence: | MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHT
PGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIV
ATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFV
AELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAK
AGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEK
NLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
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BDBM23229 |
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BDBM23230 |
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Name | BDBM23229 |
Synonyms: | Oxamic acid derivative, 7 | [(4-{2-[(5-hydroxy-2-{[(4-methoxyphenyl)methyl]carbamoyl}-4-oxo-4H-chromen-7-yl)oxy]ethyl}-2-methoxyphenyl)carbamoyl]formic acid |
Type | Small organic molecule |
Emp. Form. | C29H26N2O10 |
Mol. Mass. | 562.5241 |
SMILES | COc1ccc(CNC(=O)c2cc(=O)c3c(O)cc(OCCc4ccc(NC(=O)C(O)=O)c(OC)c4)cc3o2)cc1 |
Structure |
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