| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Malate dehydrogenase, cytoplasmic |
|---|
| Ligand | BDBM23224 |
|---|
| Substrate/Competitor | BDBM23230 |
|---|
| Meas. Tech. | Lactate Dehydrogenase Inhibition Assay |
|---|
| IC50 | >232000±n/a nM |
|---|
| Citation |  Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Malate dehydrogenase, cytoplasmic |
|---|
| Name: | Malate dehydrogenase, cytoplasmic |
|---|
| Synonyms: | Cytosolic malate dehydrogenase | MDH1 | MDHC_PIG | Malate Dehydrogenase, cytoplasmic | Malate dehydrogenase cytoplasmic |
|---|
| Type: | Oxidoreductase; homodimer |
|---|
| Mol. Mass.: | 36453.77 |
|---|
| Organism: | Sus scrofa (pig) |
|---|
| Description: | Porcine heart cytoplasmic fraction. |
|---|
| Residue: | 334 |
|---|
| Sequence: | MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKN
VIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIV
EGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
|
|
|
|---|
| BDBM23224 |
|---|
| BDBM23230 |
|---|
| Name | BDBM23224 |
|---|
| Synonyms: | 7-{[4-(formamidoformic acid)-3-methoxyphenyl]methoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15NO10 |
|---|
| Mol. Mass. | 429.3338 |
|---|
| SMILES | COc1cc(COc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
