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TargetMalate dehydrogenase cytoplasmic
LigandBDBM23224
Substrate/CompetitorBDBM23230
Meas. Tech.Lactate Dehydrogenase Inhibition Assay
IC50>232000±n/a nM
Citation Choi SRPradhan AHammond NLChittiboyina AGTekwani BLAvery MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Malate dehydrogenase cytoplasmic
Name:Malate dehydrogenase cytoplasmic
Synonyms:Cytosolic malate dehydrogenase | MDH1 | Malate Dehydrogenase, cytoplasmic
Type:Oxidoreductase; homodimer
Mol. Mass.:36453.77
Organism:Sus scrofa (pig)
Description:Porcine heart cytoplasmic fraction.
Residue:334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKN
VIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIV
EGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
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  Blast E-value cutoff:
BDBM23224
BDBM23230
NameBDBM23224
Synonyms:7-{[4-(formamidoformic acid)-3-methoxyphenyl]methoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 1
TypeSmall organic molecule
Emp. Form.C20H15NO10
Mol. Mass.429.3338
SMILESCOc1cc(COc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O
Structure
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