| Reaction Details |
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 | Report a problem with these data |
| Target | Malate dehydrogenase, cytoplasmic |
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| Ligand | BDBM23227 |
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| Substrate/Competitor | BDBM23230 |
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| Meas. Tech. | Lactate Dehydrogenase Inhibition Assay |
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| IC50 | 4880±n/a nM |
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| Citation |  Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem50:3841-50 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Malate dehydrogenase, cytoplasmic |
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| Name: | Malate dehydrogenase, cytoplasmic |
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| Synonyms: | Cytosolic malate dehydrogenase | MDH1 | MDHC_PIG | Malate Dehydrogenase, cytoplasmic | Malate dehydrogenase cytoplasmic |
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| Type: | Oxidoreductase; homodimer |
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| Mol. Mass.: | 36453.77 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Porcine heart cytoplasmic fraction. |
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| Residue: | 334 |
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| Sequence: | MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKN
VIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIV
EGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
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| BDBM23227 |
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| BDBM23230 |
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| Name | BDBM23227 |
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| Synonyms: | Oxamic acid derivative, 5 | [(4-{2-[(5-hydroxy-2-{[(4-methoxyphenyl)methyl]carbamoyl}-4-oxo-4H-chromen-7-yl)oxy]ethyl}phenyl)carbamoyl]formic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24N2O9 |
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| Mol. Mass. | 532.4982 |
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| SMILES | COc1ccc(CNC(=O)c2cc(=O)c3c(O)cc(OCCc4ccc(NC(=O)C(O)=O)cc4)cc3o2)cc1 |
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| Structure | 
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