| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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| Ligand | BDBM23334 |
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| Substrate/Competitor | BDBM23318 |
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| Meas. Tech. | Peptidyl Prolyl Isomerase (PPIase) Inibition Assay |
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| pH | 8±n/a |
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| Temperature | 273.15±n/a K |
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| Ki | 7.5±n/a nM |
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| Km | 520000±80000 nM |
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| kcat | 344±26 1/sec |
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| Citation |  Wu, YQ; Wilkinson, DE; Limburg, D; Li, JH; Sauer, H; Ross, D; Liang, S; Spicer, D; Valentine, H; Fuller, M; Guo, H; Howorth, P; Soni, R; Chen, Y; Steiner, JP; Hamilton, GS Synthesis of ketone analogues of prolyl and pipecolyl ester FKBP12 ligands. J Med Chem45:3558-68 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase FKBP1A |
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| Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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| Synonyms: | 12 kDa FKBP | FK506-binding protein 1A | FKB1A_BOVIN | FKBP-12 | FKBP1 | FKBP1A | Immunophilin FKBP12 | PPIase | Rotamase |
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| Type: | Isomerase |
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| Mol. Mass.: | 11911.51 |
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| Organism: | Bos taurus (bovine) |
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| Description: | The enzyme was purified from calf thymus. The collected protein was further applied to Sephacryl column, and the fraction contained high PPIase activity was pooled. |
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| Residue: | 108 |
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| Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFVLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPNATLIFDVELLKLE
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| BDBM23334 |
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| BDBM23318 |
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| Name | BDBM23334 |
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| Synonyms: | 3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylate | CHEMBL6367 | GPI 1046 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28N2O4 |
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| Mol. Mass. | 360.4473 |
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| SMILES | CCC(C)(C)C(=O)C(=O)N1CCC[C@H]1C(=O)OCCCc1cccnc1 |r| |
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| Structure | 
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