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TargetPeptidyl-prolyl cis-trans isomerase FKBP1A
LigandBDBM23348
Substrate/CompetitorBDBM23318
Meas. Tech.Peptidyl Prolyl Isomerase (PPIase) Inibition Assay
pH8±n/a
Temperature288.15±n/a K
Ki 60±n/a nM
Citation Hudack RABarta NSGuo CDeal JDong LFay LKCaprathe BChatterjee AVanderpool DBigge CShowalter RBender SAugelli-Szafran CELunney EHou X Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands. J Med Chem 49:1202-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP1A
Name:RyR1/FKBP12
Synonyms:12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKBP-12 | FKBP-1A | FKBP12 | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase
Type:Isomerase
Mol. Mass.:11953.09
Organism:Homo sapiens (Human)
Description:P62942
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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  Blast E-value cutoff:
BDBM23348
BDBM23318
NameBDBM23348
Synonyms:1-{4,6-dimethoxy-12-oxo-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-trien-17-yl}-2-(3,4-dimethoxyphenyl)ethane-1,2-dione | Tetracyclic aza-amide, 6d
TypeSmall organic molecule
Emp. Form.C27H30N2O7
Mol. Mass.494.5363
SMILESCOc1cc2CCN3C(C4CCCC(N4C(=O)C(=O)c4ccc(OC)c(OC)c4)C3=O)c2c(OC)c1 |TLB:15:14:10.11.12:7.8.29|
Structure
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