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TargetPeptidyl-prolyl cis-trans isomerase FKBP1A
LigandBDBM23349
Substrate/CompetitorBDBM23318
Meas. Tech.Peptidyl Prolyl Isomerase (PPIase) Inibition Assay
pH8±n/a
Temperature288.15±n/a K
Ki 71±n/a nM
Citation Hudack, RABarta, NSGuo, CDeal, JDong, LFay, LKCaprathe, BChatterjee, AVanderpool, DBigge, CShowalter, RBender, SAugelli-Szafran, CELunney, EHou, X Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands. J Med Chem49:1202-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP1A
Name:Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:Isomerase
Mol. Mass.:11953.09
Organism:Homo sapiens (Human)
Description:P62942
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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  Blast E-value cutoff:
BDBM23349
BDBM23318
NameBDBM23349
Synonyms:1-(4-bromophenyl)-2-{4,6-dimethoxy-12-oxo-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-trien-17-yl}ethane-1,2-dione | Tetracyclic aza-amide, 6e
TypeSmall organic molecule
Emp. Form.C25H25BrN2O5
Mol. Mass.513.38
SMILESCOc1cc2CCN3C(C4CCCC(N4C(=O)C(=O)c4ccc(Br)cc4)C3=O)c2c(OC)c1 |TLB:15:14:10.11.12:7.8.26|
Structure
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