Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM23376 |
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Substrate/Competitor | BDBM23318 |
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Meas. Tech. | Peptidyl Prolyl Isomerase (PPIase) Inibition Assay |
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Ki | 92±n/a nM |
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Citation | Hudack, RA; Barta, NS; Guo, C; Deal, J; Dong, L; Fay, LK; Caprathe, B; Chatterjee, A; Vanderpool, D; Bigge, C; Showalter, R; Bender, S; Augelli-Szafran, CE; Lunney, E; Hou, X Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands. J Med Chem49:1202-6 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FKBP | FK506-binding protein 1A | FKB1A_BOVIN | FKBP-12 | FKBP1 | FKBP1A | Immunophilin FKBP12 | PPIase | Rotamase |
Type: | Isomerase |
Mol. Mass.: | 11911.51 |
Organism: | Bos taurus (bovine) |
Description: | The enzyme was purified from calf thymus. The collected protein was further applied to Sephacryl column, and the fraction contained high PPIase activity was pooled. |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFVLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPNATLIFDVELLKLE
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BDBM23376 |
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BDBM23318 |
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Name | BDBM23376 |
Synonyms: | 17-[(4-bromobenzene)sulfonyl]-4,6-dimethoxy-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-trien-12-one | Tetracyclic aza-amide, 12e |
Type | Small organic molecule |
Emp. Form. | C23H25BrN2O5S |
Mol. Mass. | 521.424 |
SMILES | COc1cc2CCN3C(C4CCCC(N4S(=O)(=O)c4ccc(Br)cc4)C3=O)c2c(OC)c1 |TLB:15:14:10.11.12:7.8.25| |
Structure |
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