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TargetPeptidyl-prolyl cis-trans isomerase FKBP1A
LigandBDBM23376
Substrate/CompetitorBDBM23318
Meas. Tech.Peptidyl Prolyl Isomerase (PPIase) Inibition Assay
Ki 92±n/a nM
Citation Hudack, RABarta, NSGuo, CDeal, JDong, LFay, LKCaprathe, BChatterjee, AVanderpool, DBigge, CShowalter, RBender, SAugelli-Szafran, CELunney, EHou, X Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands. J Med Chem49:1202-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase FKBP1A
Name:Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:12 kDa FKBP | FK506-binding protein 1A | FKB1A_BOVIN | FKBP-12 | FKBP1 | FKBP1A | Immunophilin FKBP12 | PPIase | Rotamase
Type:Isomerase
Mol. Mass.:11911.51
Organism:Bos taurus (bovine)
Description:The enzyme was purified from calf thymus. The collected protein was further applied to Sephacryl column, and the fraction contained high PPIase activity was pooled.
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFVLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPNATLIFDVELLKLE
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BDBM23376
BDBM23318
NameBDBM23376
Synonyms:17-[(4-bromobenzene)sulfonyl]-4,6-dimethoxy-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-trien-12-one | Tetracyclic aza-amide, 12e
TypeSmall organic molecule
Emp. Form.C23H25BrN2O5S
Mol. Mass.521.424
SMILESCOc1cc2CCN3C(C4CCCC(N4S(=O)(=O)c4ccc(Br)cc4)C3=O)c2c(OC)c1 |TLB:15:14:10.11.12:7.8.25|
Structure
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