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TargetImmunophilin FKBP12
LigandBDBM23378
Substrate/CompetitorBDBM23318
Meas. Tech.Peptidyl Prolyl Isomerase (PPIase) Inibition Assay
Ki 156±n/a nM
Citation Hudack RABarta NSGuo CDeal JDong LFay LKCaprathe BChatterjee AVanderpool DBigge CShowalter RBender SAugelli-Szafran CELunney EHou X Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands. J Med Chem 49:1202-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Immunophilin FKBP12
Name:Immunophilin FKBP12
Synonyms:12 kDa FKBP | FK506-binding protein 1A | FKBP-12 | PPIase | Rotamase
Type:Isomerase
Mol. Mass.:11911.51
Organism:Bos taurus (bovine)
Description:The enzyme was purified from calf thymus. The collected protein was further applied to Sephacryl column, and the fraction contained high PPIase activity was pooled.
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFVLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPNATLIFDVELLKLE
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BDBM23378
BDBM23318
NameBDBM23378
Synonyms:17-{[4-(3,4-dichlorophenyl)benzene]sulfonyl}-4,6-dimethoxy-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-trien-12-one | Tetracyclic aza-amide, 12g
TypeSmall organic molecule
Emp. Form.C29H28Cl2N2O5S
Mol. Mass.587.514
SMILESCOc1cc2CCN3C(C4CCCC(N4S(=O)(=O)c4ccc(cc4)-c4ccc(Cl)c(Cl)c4)C3=O)c2c(OC)c1 |TLB:15:14:10.11.12:7.8.32|
Structure
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