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TargetImmunophilin FKBP12
LigandBDBM23389
Substrate/CompetitorBDBM23318
Meas. Tech.Peptidyl Prolyl Isomerase (PPIase) Inibition Assay
Ki 183±n/a nM
Citation Hudack RABarta NSGuo CDeal JDong LFay LKCaprathe BChatterjee AVanderpool DBigge CShowalter RBender SAugelli-Szafran CELunney EHou X Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands. J Med Chem 49:1202-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Immunophilin FKBP12
Name:Immunophilin FKBP12
Synonyms:12 kDa FKBP | FK506-binding protein 1A | FKBP-12 | PPIase | Rotamase
Type:Isomerase
Mol. Mass.:11911.51
Organism:Bos taurus (bovine)
Description:The enzyme was purified from calf thymus. The collected protein was further applied to Sephacryl column, and the fraction contained high PPIase activity was pooled.
Residue:108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFVLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPNATLIFDVELLKLE
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BDBM23389
BDBM23318
NameBDBM23389
Synonyms:N-(6-fluoropyridin-3-yl)-6-methoxy-12-oxo-11,17-diazatetracyclo[11.3.1.0^{2,11}.0^{3,8}]heptadeca-3(8),4,6-triene-17-sulfonamide | Tetracyclic aza-amide, 14c
TypeSmall organic molecule
Emp. Form.C21H23FN4O4S
Mol. Mass.446.495
SMILESCOc1ccc2C3C4CCCC(N4S(=O)(=O)Nc4ccc(F)nc4)C(=O)N3CCc2c1 |TLB:13:12:8.9.10:26.6.24|
Structure
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