| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-amylase 1A |
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| Ligand | BDBM23419 |
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| Substrate/Competitor | BDBM23407 |
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| Meas. Tech. | In Vitro alpha-Amylase Activity Assay |
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| pH | 6±n/a |
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| Temperature | 295.15±n/a K |
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| Comments | 26.8% inhibition uM. |
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| Citation |  Lo Piparo, E; Scheib, H; Frei, N; Williamson, G; Grigorov, M; Chou, CJ Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase. J Med Chem51:3555-61 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Alpha-amylase 1A |
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| Name: | Alpha-amylase 1A |
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| Synonyms: | 1,4-alpha-D-glucan glucanohydrolase 1 | AMY1 | AMY1A | AMY1A_HUMAN | Alpha-amylase | Salivary alpha-amylase |
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| Type: | Glycosidase |
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| Mol. Mass.: | 57770.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Sigma Chemical Co. |
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| Residue: | 511 |
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| Sequence: | MKLFWLLFTIGFCWAQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPP
NENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGN
AVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGL
LDLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASKHMWPGDIKAILDKLHNLNSNWFPEG
SKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWG
FMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWP
RYFENGKDVNDWVGPPNDNGVTKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQP
FTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGI
KIYVSDDGKAHFSISNSAEDPFIAIHAESKL
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| BDBM23419 |
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| BDBM23407 |
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| Name | BDBM23419 |
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| Synonyms: | (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one | CHEMBL9352 | Naringenin |
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| Type | flavanone |
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| Emp. Form. | C15H12O5 |
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| Mol. Mass. | 272.2528 |
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| SMILES | Oc1ccc(cc1)[C@@H]1CC(=O)c2c(O)cc(O)cc2O1 |r| |
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| Structure | 
|
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