| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor XII |
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| Ligand | BDBM23562 |
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| Substrate/Competitor | BDBM12680 |
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| Meas. Tech. | IC50 Value Determination |
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| pH | 7.9±n/a |
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| Temperature | 295.15±n/a K |
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| Comments | No inhibition uM. |
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| Citation |  Robert, S; Bertolla, C; Masereel, B; Dogné, JM; Pochet, L Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors. J Med Chem51:3077-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Coagulation factor XII |
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| Name: | Coagulation factor XII |
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| Synonyms: | Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | Coagulation factor XII (FXII) | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | FA12_HUMAN | Factor XIIa | Factor XIIa (fXIIa) | HAF | Hageman factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 67810.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00748 |
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| Residue: | 615 |
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| Sequence: | MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS
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| BDBM23562 |
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| BDBM12680 |
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| Name | BDBM23562 |
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| Synonyms: | 3-Carboxylate-coumarin deriv., 2 | phenyl 6-methyl-2-oxo-2H-chromene-3-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12O4 |
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| Mol. Mass. | 280.2748 |
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| SMILES | Cc1ccc2oc(=O)c(cc2c1)C(=O)Oc1ccccc1 |
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| Structure | 
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