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TargetNeutrophil elastase
LigandBDBM23721
Substrate/CompetitorBDBM23699
Meas. Tech.Human Neutrophil Elastase Inhibition Assay
pH7.5±n/a
Temperature298.15±n/a K
Ki 9000±n/a nM
Citation Schepetkin, IAKhlebnikov, AIQuinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem50:4928-38 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Neutrophil elastase
Name:Neutrophil elastase
Synonyms:Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:Enzyme
Mol. Mass.:28532.38
Organism:Homo sapiens (Human)
Description:P08246
Residue:267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM23721
BDBM23699
NameBDBM23721
Synonyms:4-chloro-1-[(2-fluorophenyl)carbonyl]-3,5-dimethyl-1H-pyrazole | N-Benzoylpyrazole deriv., 29
TypeSmall organic molecule
Emp. Form.C12H10ClFN2O
Mol. Mass.252.672
SMILESCc1nn(C(=O)c2ccccc2F)c(C)c1Cl
Structure
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