| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aminopeptidase N |
|---|
| Ligand | BDBM23708 |
|---|
| Substrate/Competitor | BDBM23736 |
|---|
| Meas. Tech. | Human Neutrophil Elastase Inhibition Assay |
|---|
| Citation |  Schepetkin, IA; Khlebnikov, AI; Quinn, MT N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase. J Med Chem50:4928-38 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Aminopeptidase N |
|---|
| Name: | Aminopeptidase N |
|---|
| Synonyms: | AMPN_PIG | ANPEP | AP-M | AP-N | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N (APN) | CD_antigen=CD13 | Microsomal aminopeptidase | gp130 | pAPN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 108810.25 |
|---|
| Organism: | Sus scrofa (Pig) |
|---|
| Description: | P15145 |
|---|
| Residue: | 963 |
|---|
| Sequence: | MAKGFYISKALGILGILLGVAAVATIIALSVVYAQEKNKNAEHVPQAPTSPTITTTAAIT
LDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRLLCQEPTDVIIIHS
KKLNYTTQGHMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGSLQPGHMYEMESEFQGE
LADDLAGFYRSEYMEGNVKKVLATTQMQSTDARKSFPCFDEPAMKATFNITLIHPNNLTA
LSNMPPKGSSTPLAEDPNWSVTEFETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWAR
PNAIAEGHGMYALNVTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYREN
ALLFDPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEYLGADHA
EPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQISEMFDSISYSKGASVIR
MLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWEHLQKAVDAQTSIRLPDTVRAIMDRWT
LQMGFPVITVDTKTGNISQKHFLLDSESNVTRSSAFDYLWIVPISSIKNGVMQDHYWLRD
VSQAQNDLFKTASDDWVLLNVNVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIY
DSFNLATAHMVPVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLR
KQVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKTLFDQWMSDP
ENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNEADKLRSALACSNEVWLLNR
YLGYTLNPDLIRKQDATSTINSIASNVIGQPLAWDFVQSNWKKLFQDYGGGSFSFSNLIQ
GVTRRFSSEFELQQLEQFKKNNMDVGFGSGTRALEQALEKTKANIKWVKENKEVVLNWFI
EHS
|
|
|
|---|
| BDBM23708 |
|---|
| BDBM23736 |
|---|
| Name | BDBM23708 |
|---|
| Synonyms: | 4-bromo-1-[(2,6-difluorophenyl)carbonyl]-1H-pyrazole | N-Benzoylpyrazole deriv., 13 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H5BrF2N2O |
|---|
| Mol. Mass. | 287.06 |
|---|
| SMILES | Fc1cccc(F)c1C(=O)n1cc(Br)cn1 |
|---|
| Structure | 
|
|---|
Search and Browse
